Increased oxidative stress has been suggested in the pathogenesis and progression of hyperlipidemia and its associated complications such as atherosclerosis, myocardial infarction, and poor wound healing. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to the prevalence and severity of coronary heart diseases. Hyperlipidemia is the primary cause of death & characterized by elevated total serum cholesterol, low density lipoprotein, very low density lipoprotein and decreased high density lipoprotein levels. The main aim of the study was to reduce the risk of developing ischemic heart disease or the occurance of further cardiovascular disease or cerebrovascular disease. Currently available synthetic hypolipidemic drugs have been associated with number of side effects such as hyperuricemic, diarrhoea, nausea, myositis, gastric irritation, flushing, dry skin and abnormal liver function. Herbal medicines are often used as remedies to treat hyperlipidemia. Gymnema Sylvestre can cure hyperlipidemia as mentioned in the literature survey in traditional Indian system of medicine and is not proved scientifically so the aim of the present study is to determine the effect of Ethanolic aerial part extract of Gymnema Sylvestre on hyperlipidemia. In the study we induce hyperlipidemia by Triton X-100 in rats. Ethanolic extract of plant was obtained by Soxhlet extraction. Ethanolic extract at a dose of 200mg/kg causes reduction in total body weight, total serum cholesterol & triglycerides when compared to untreated groups. Values are expressed as mean �± S.E.M. Fenofibrate (65mg/kg) was used as standard drug.
Loading....